In a new study, a team of international researchers The system was hijacked Toxoplasma Applications The researchers genetically engineered the bacteria to secrete proteins into the host cell. Toxoplasma One of the secreted proteins is fused to create a hybrid protein, A protein called MECP2regulates gene activity in the brain, in effect piggybacking MECP2 onto neurons. The researchers found that the parasite secreted MECP2 protein hybrids into neurons cultured in petri dishes, as well as into the brains of infected mice.
Genetic defects in MECP2 cause a rare disorder of brain development. Rett SyndromeGene Therapy Trials Using a virus to deliver MECP2 protein Research is ongoing into treating Rett syndrome. Toxoplasma Delivering a version of the MECP2 protein to brain cells may provide a new option for treating this currently untreatable disease, as well as other neurological problems that result from abnormal proteins. Alzheimer’s disease, etc. and Parkinson’s disease.
The long road ahead
of The journey from bench to bedside It’s long and has lots of obstacles, so don’t expect anything manmade. Toxoplasma I’m going to the clinic soon.
Apparent complexity in use Toxoplasma The main problem with it not being recommended for medical use is that it can cause serious, lifelong infections that are currently incurable. Toxoplasma can Damage to vital organ systemsThis includes the brain, eyes, heart, etc.
but, One third of the world’s people Currently held Toxoplasma The infection continues silently in the brain. New research shows a correlation between the infection and an increased risk of schizophrenia, rage disorder, and reckless behavior, and this silent infection may be Tends to cause serious neurological problems in some people.
Widespread spread of Toxoplasma Infection is another possible complication, making many people unable to treat it. Billions of people who already carry the parasite have developed immunity to future infections, making them unable to treat it. Toxoplasma Once injected, it is rapidly destroyed by the immune system.
In some cases, Toxoplasma The benefits of using it as a drug delivery system may outweigh the risks: by modifying a benign form of the parasite, it could potentially produce proteins patients need without harming the organ that defines our identity: the brain.
