background
Scorpions have evolved highly efficient venoms that serve both to capture prey and for self-defense. Consequently, peptides isolated from the venoms of various scorpion species show great potential for new drug development.
the purpose
This systematic review provides an overview of the therapeutic potential of peptides isolated from scorpion venoms that act on the cardiovascular system.
method
We use the terms “peptide”, “scorpion”, “bradykinin enhancer”, and “impact on cardiovascular disease” in PubMed, Scopus, Web of Science, EMBASE, and Virtual Health Library in 2023. We systematically searched for relevant studies published up to December. and “hypertensive effect.”
result
The literature search yielded 240 references. After applying the inclusion criteria, 17 studies were selected for analysis. Our review yielded five important findings. First, the identification of a canonical bradykinin-enhancing peptide that acts as an angiotensin-converting enzyme inhibitor and a non-canonical bradykinin-enhancing peptide that acts as a B2 receptor agonist and potentiates the physiological effects of angiotensin-converting enzyme. bradykinin. Second, peptides were discovered that regulate cardiomyocyte proteins. Third, inotropic peptides were identified. Fourth, potent hERG blocker peptides were discovered. Finally, a peptide with significant sodium current blocking ability in ventricular myocytes was identified.
conclusion
The high specificity and potency of these scorpion venom-derived molecules highlight their potential as novel therapeutic agents in the cardiovascular field. This study highlights the importance of exploring natural bioactive compounds to develop innovative treatments for cardiovascular diseases.
Santos, FF, Silva, M. & de Matos, IM Scorpion venom peptides as therapeutic agents for cardiovascular diseases: a systematic review. Int J Pept Res Ther 3112 (2025). https://doi.org/10.1007/s10989-024-10671-1
