Loxocele spider venom from southeastern and northeastern Brazil causes haemotoxicity in human blood components
abstract
genus spider Loxoceles Due to the serious skin and systemic effects that can be caused by bites, it is a public health problem in Brazil. In the systemic form of loxoselism, hemolytic anemia, thrombocytopenia, and disseminated intravascular coagulation may occur. Despite the seriousness of Loxoceles Due to accidents occurring, the venoms of some species have not yet been properly characterized considering their hematotoxic effects. Loxoceles Amazonica, Loxoceles aff. Variegataand loxoceles analogs. To better understand their potential toxicity, this study aimed to characterize their hematotoxic properties. Loxoceles poison. Crude toxin was obtained from the following specimens: L. Amazonica, L.aff.variegataand L. similis Obtainable from Arachnids in Hunedo. In washed platelets, L.aff.variegata inhibited platelet aggregation induced by collagen and conbulxin; L. Amazonica and L. similis The venom was able to induce platelet aggregation. In in vitro hemolysis assays, all venoms experimentally induced direct hemolysis of human red blood cells at different intensities in a concentration-dependent manner. Additionally, there is evidence to suggest that the ABO and Rh systems may influence hemolytic activity. Finally, I learned Loxoceles The venom degrades fibrinogen, suggesting possible changes in the coagulation cascade. Based on the preliminary studies presented here, in vivo assays in model animals are needed to verify the actual toxic potential of these species’ venoms and to build knowledge to elucidate their venom effects. is. Loxoceles poison in the blood.
