Scorpion venom-resistant synthetic peptides alleviate neuronecrosis in Alzheimer’s disease model by modulating LNC GM6410 under PM2.5 exposure

Abstract

Recent epidemiological studies have shown exposure to particulate matter with aerodynamic diameters of less than 2.5 μm in ambient air (PM)2.5) is significantly associated with increased risk of developing Alzheimer’s disease (AD) and its progression. Scorpion venom-resistant synthetic peptide (SVHRSP) exhibits anti-inflammatory and neuroprotective properties. However, an accurate way for SVHRSP to reduce PM-induced AD progression2.5 Not yet known. Long non-coding RNAs (LNCRNAs) play an important role in a variety of biological processes. Necroptosis, a form of programmed cell death, has attracted considerable attention in recent years. The purpose of this study is to investigate whether LNC GM16410 and neural necrosis are involved in PM.2.5– We extended the mechanism of AD progression and SVHRSP in mitigating this process. Through the establishment of PM2.5 The exposure model of AD mice and in vitro models, PM was discovered.2.5 Exposure may promote necroptosis and downregulation of LNC GM16410, thereby promoting AD progression. Behavioral tests showed that SVHRSP alleviated cognitive impairment in PM2.5– Induced AD mice. WB, QRT-PCR, and other molecular biological assays show that LNC GM16410 regulates neural necrosis under PM2.5 Exposure via the P38 MAPK pathway. SVHRSP is a potential regulator of AD progression by tuning the LNC GM16410 to mitigate PM.2.5 Exposure-induced necroptosis. These findings provide new insights into mechanisms through PM2.5 Exposure accelerates the progression of AD examined from the lncRNA perspective. Additionally, it provides new targets for the treatment and prevention of AD after PM2.5 Exposure by investigating the mechanism of action of SVHRSP in alleviating AD.